PARN anticorps

N° du produit ABIN7464840

Cet anticorps Lapin Polyclonal détecte spécifiquement PARN dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour PARN anticorps (ABIN7464840)

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARN est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Classe de qualité: KO Validated

Détail du produit anti-PARN anticorps

Specificité: Knockdown/Knockout validation was supported by references (PMID:26990993)

Réactivité croisée: Humain, Souris

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human PARN. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: NIH-3T3 , BCL-1

Validation: KO/KD

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur PARN

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Autre désignation: poly(A)-specific ribonuclease

Sujet: Poly(A)-specific ribonuclease , DAN , DKCB6 , PFBMFT4,The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Poids moléculaire: 73 kDa

ID gène: 5073

UniProt: O95453