USP20 anticorps

N° du produit ABIN7465301

Cet anticorps anti-USP20 est un anticorps Lapin Polyclonal détectant USP20 dans WB. Adapté pour Humain.

Aperçu rapide pour USP20 anticorps (ABIN7465301)

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP20 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-USP20 anticorps

Réactivité croisée: Humain

Purification: Affinity purified by Protein A.

Immunogène: Recombinant protein encompassing a sequence within the center region of human USP20. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: 293T , Raji

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.98 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur USP20

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Autre désignation: ubiquitin specific peptidase 20

Sujet: Ubiquitin specific peptidase 20 , LSFR3A , VDU2 , hVDU2,Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Poids moléculaire: 102 kDa

ID gène: 10868

UniProt: Q9Y2K6

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling