Retinoblastoma Binding Protein 4 anticorps (AA 1-425)

N° du produit ABIN7468875

Cet anticorps Souris Monoclonal détecte spécifiquement Retinoblastoma Binding Protein 4 dans WB, IHC, IF, IP et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour Retinoblastoma Binding Protein 4 anticorps (AA 1-425) (ABIN7468875)

Antigène: Retinoblastoma Binding Protein 4 (RBBP4)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoblastoma Binding Protein 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: 13D10

Détail du produit anti-Retinoblastoma Binding Protein 4 anticorps

Épitope: AA 1-425

Réactivité croisée: Humain

Purification: Protein G purified

Immunogène: The complete coding region (amino acids 1-425) of RbAp48 expressed in E. coli.

Isotype: IgG2b

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: HeLa nuclear extract , SH-SY-5Y , SH-SY-5Y nuclear extract Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur Retinoblastoma Binding Protein 4

Antigène: Retinoblastoma Binding Protein 4 (RBBP4)

Autre désignation: RB binding protein 4, chromatin remodeling factor

Sujet:

Synonyms: RB binding protein 4, chromatin remodeling factor , NURF55 , RBAP48 , lin-53

Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Poids moléculaire: 48 kDa

ID gène: 5928

UniProt: Q09028

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus