SCIMP anticorps (PE)

N° du produit ABIN7506008

Cet anticorps anti-SCIMP est un anticorps Souris Monoclonal détectant SCIMP dans ICFC. Adapté pour Humain.

Aperçu rapide pour SCIMP anticorps (PE) (ABIN7506008)

Antigène: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCIMP est conjugé à/à la PE

Application: Intracellular Flow Cytometry (ICFC)

Clone: NVL-07

Détail du produit anti-SCIMP anticorps (PE)

Fonction: Anti-SCIMP PE

Specificité: The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Recombinant intracellular part of human SCIMP

Isotype: IgG2a

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Détails sur SCIMP

Antigène: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Autre désignation: SCIMP

Sujet: SLP adaptor and CSK interacting membrane protein,SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.,NVL

ID gène: 388325

UniProt: Q6UWF3