EPH Receptor A7 anticorps (AA 181-280) (Biotin)

N° du produit ABIN722007

Cet anticorps anti-EPH Receptor A7 est un anticorps Lapin Polyclonal détectant EPH Receptor A7 dans WB, ELISA, IHC (p) et IHC (fro). Adapté pour Humain, Rat et Souris.

Aperçu rapide pour EPH Receptor A7 anticorps (AA 181-280) (Biotin) (ABIN722007)

Antigène: EPH Receptor A7 (EPHA7)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A7 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-EPH Receptor A7 anticorps (Biotin)

Épitope: AA 181-280

Specificité: There is a chance that this protein will cross-react with EphA4 based on a 73 % non-sequential sequence similarity.

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EphA7

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur EPH Receptor A7

Antigène: EPH Receptor A7 (EPHA7)

Autre désignation: EphA7

Sujet:

Synonyms: EHK3, EK11, EHK-3, HEK11, Ephrin type-A receptor 7, EPH homology kinase 3, EPH-like kinase 11, EPHA7

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

ID gène: 2045

UniProt: Q15375

Pathways: Signalisation RTK