Acetylcholinesterase anticorps

N° du produit ABIN7539781

L’anticorps anti-Acetylcholinesterase Monoclonal Souris est utilisé pour la détection de Acetylcholinesterase dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour WB, IHC et FACS.

Aperçu rapide pour Acetylcholinesterase anticorps (ABIN7539781)

Antigène: Acetylcholinesterase (AChE)

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Acetylcholinesterase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 3D5E8

Détail du produit anti-Acetylcholinesterase anticorps

Fonction: ACHE Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human ACHE expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur Acetylcholinesterase

Antigène: Acetylcholinesterase (AChE)

Autre désignation: ACHE

Sujet: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion.

Poids moléculaire: 67.8 kDa

ID gène: 43

UniProt: P22303

Pathways: Skeletal Muscle Fiber Development