Calnexin anticorps (C-Term)

N° du produit ABIN7540514

N° du produit (Fournisseur): 200-401-e97

Cet anticorps Lapin Polyclonal détecte spécifiquement Calnexin dans WB, IHC, IF, IP et FACS. Il présente une réactivité envers Chien.

Aperçu rapide pour Calnexin anticorps (C-Term) (ABIN7540514)

Antigène: Calnexin (CANX)

Reactivité: Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calnexin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)

Détail du produit anti-Calnexin anticorps

Épitope: C-Term

N° du produit (Fournisseur): 200-401-e97

Fournisseur: Rockland

Fonction: Calnexin-CT Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with Calnexin -CT from Human, Monkey, Mouse, Rat, Bovine, Chicken (weak), Dog, Guinea pig, Hamster, Pig, Quail, Rabbit, Sheep, Drosophila (weak), and Xenopus (weak) based on 100 % homology with the immunizing sequence.

Purification: Anti-Calnexin -CT Antibody was purified by Protein A chromatography.

Stérilité: Sterile filtered

Immunogène: Calnexin-CT Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to the C-terminal region of dog calnexin. Identical to human, mouse and rat calnexin sequences over these residues.

Isotype: IgG

Information d'application

Indications d'application:

Immunoprecipitation_Dilution: User Optimized

Immunohistochemistry_Dilution: User Optimized

Flow_Cytometry_Dilution: User Optimized

Western_Blot_Dilution: 1:2000

Commentaires:

Anti-Calnexin-CT Antibody is tested for use in WB, IP, IF microscopy, IHC and Flow Cytometry. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.1 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Calnexin

Antigène: Calnexin (CANX)

Autre désignation: CANX

Sujet: CANX, CNX, IP90, P90, Calnexin, pp90,Calnexin, an abundant ~90 kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90. It consists of a large 50 kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail. Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention, calnexin has positively charged cytosolic residues that do the same thing. Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multi-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans. Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin.

ID gène: 403908

NCBI Accession: NP_001003232

UniProt: P24643

Pathways: Signalisation MAPK, Thyroid Hormone Synthesis