UCHL1 anticorps

N° du produit ABIN7540520

N° du produit (Fournisseur): 200-901-e52

Cet anticorps Poulet Polyclonal détecte spécifiquement UCHL1 dans WB, ELISA, IF, FM et MA. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour UCHL1 anticorps (ABIN7540520)

Antigène: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reactivité: Humain

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp UCHL1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Fluorescence Microscopy (FM), Multiplex Assay (MA)

Détail du produit anti-UCHL1 anticorps

N° du produit (Fournisseur): 200-901-e52

Fournisseur: Rockland

Fonction: Ubiquitin Hydrolase (UCHL1) Antibody

Réactivité croisée (Details): Anti-UCHL1 antibody is directed against human UCHL1 proteins.

Purification: The antibody was purified from chicken eggs as an IgY fraction.

Immunogène: Anti-UCHL1 Antibody was produced in chicken by repeated immunizations with recombinant full length human UCHL1 extensively purified from E. coli.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:25,000

IF_Microscopy_Dilution: 1:500

Western_Blot_Dilution: 1:2500

Commentaires:

Suggested Applications: Other
Anti-Ubiquitin Hydrolase antibody is tested for use in Western Blotting and IF. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 24 kDa in size corresponding to the UCHL1 proteins in Western blots in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-UCHL1 (ABIN7540520)

Guseva, Rizvanov, Salafutdinov, Kudryashova, Palotás, Islamov: "Over-expression of Oct4 and Sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo." dans: Biochemical and biophysical research communications, Vol. 451, Issue 4, pp. 503-9, (2014) (PubMed).

Détails sur UCHL1

Antigène: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Autre désignation: UCHL1

Sujet: UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Ubiquitin thioesterase L1,UCHL1 antibody recognizes Ubiquitin C-terminal hydrolase 1 (UCHL1) which is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker. Therefore, UCHL1 antibody is ideal for investigators involved in neuronal disorders and, more generally in Neuroscience.

ID gène: 7345

UniProt: P09936

Pathways: Feeding Behaviour