Menin anticorps (C-Term)

N° du produit ABIN7540526

N° du produit (Fournisseur): 200-901-mj8

Cet anticorps Poulet Polyclonal détecte spécifiquement Menin dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour Menin anticorps (C-Term) (ABIN7540526)

Antigène: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Reactivité: Humain

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp Menin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-Menin anticorps

Épitope: C-Term

N° du produit (Fournisseur): 200-901-mj8

Fournisseur: Rockland

Fonction: Anti-MEN1 Antibody

Réactivité croisée (Details): This affinity purified antibody is directed against human Menin1.

Purification: This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above.

Stérilité: Sterile filtered

Immunogène: Anti-Menin1 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a C-Terminal portion of human MEN1 conjugated to Keyhole Limpet Hemocyanin (KLH).

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000-1:50,000

Immunohistochemistry_Dilution: 1:500

Western_Blot_Dilution: 1 μg/mL

Commentaires:

Anti-MEN1 Antibody has been tested in Western Blot and Immunohistochemistry.  Expect a band at ~67.5, 68kDa in western blot using appropriate tissues and lysates.  Anti-Menin1 should only be used for overexpressing conditions in western blot. Positive control used: Human Colon in IHC.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.002 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.0

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Menin

Antigène: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Autre désignation: MEN1

Sujet: Chicken Anti-Menin1 Antibody, Menin 1, Menin, SCG2, Multiple Endocrine Neoplasia I, MEAI,Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Anti-MEN1 Antibody is useful for researchers interested in Multiple Endocrine Neoplasia Type I, Insulinoma, Cancer Research and Epigenetic Research.

ID gène: 4221

NCBI Accession: NP_000235

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity