Recombinant GDF8 (Lintuzumab Biosimilar) anticorps

N° du produit ABIN7543069

Cet anticorps anti-GDF8 (Lintuzumab Biosimilar) Chimeric Lapin (Clone SGN-33) (ABIN7543069) détecte spécifiquement GDF8 (Lintuzumab Biosimilar) dans Func. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant GDF8 (Lintuzumab Biosimilar) anticorps (ABIN7543069)

Antigène: GDF8 (Lintuzumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Inconjugué

Application: Functional Studies (Func)

Clone: SGN-33

Détail du produit

Fonction: Anti-CD33 [SGN-33 (Lintuzumab)], Rabbit IgG, kappa

Specificité: This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases.

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: This humanized antibody was prepared by combining the CDR regions of the murine anti-CD33 M195 with human framework and constant regions.

Isotype: IgG kappa

Information d'application

Indications d'application: In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005).

Commentaires:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: GDF8 (Lintuzumab Biosimilar)

Autre désignation: CD33 (Lintuzumab Biosimilar)

Classe de substances: Biosimilar

Sujet: Sialic acid-binding Ig-like lectin 3, gp67, HuM195

UniProt: P20138