Recombinant beta Amyloid anticorps

N° du produit ABIN7543179

L’anticorps Human Chimeric anti-beta Amyloid a été validé pour WB, ELISA, IHC et IP. Il convient pour détecter beta Amyloid dans des échantillons de Humain.

Aperçu rapide pour Recombinant beta Amyloid anticorps (ABIN7543179)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Human

Clonalité: Chimeric

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 21F12

Détail du produit anti-beta Amyloid anticorps

Fonction: Anti-Amyloid Beta [21F12], Human IgG1, kappa

Specificité: This antibody recognizes amino acids 33-42 of amyloid beta.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG2b

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing A/J mice with a synthetic peptide (NH2-CYS-NH-CH2-(CH2)5-CO-GLMVGGVVIA-COOH) as an immunogen.

Isotype: IgG1 kappa

Information d'application

Indications d'application: This antibody has very high specificity for Aβ1-42 over Aβ1-40. This antibody is capable of immunoprecipitating Aβ peptides ending at aa position 42 and also p3 peptides (PMID: 8917563). This antibody is also recomended for detection of amyloid beta using sandwich ELISA (PMID: 9037091, 19204155). This antibody was also used in the quantification of the proportion of full-length Aβ using western blotting (PMID: 12787077). This antibody has also been used for the identification of Aβ42 plaques on paraffin frontal sections(PMID: 15215183, 19660650). This antibody is unable to bind plaques in unfixed brain sections. This antibody is also not capable of clearing plaque after in vivo administration (PMID: 10932230).

Commentaires:

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid Beta

Sujet: Abeta, A-beta, Aβ, Aβ42, Alzheimer disease amyloid protein, S-APP-beta

UniProt: P05067

Pathways: Inflammasome