Recombinant p40 (p63 Delta) (AA 4-19) anticorps

N° du produit ABIN7543297

Cet anticorps anti- est un anticorps Souris Monoclonal détectant dans IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour Recombinant p40 (p63 Delta) (AA 4-19) anticorps (ABIN7543297)

Antigène: p40 (p63 Delta)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), ELISA

Clone: 14D5E8F12

Détail du produit

Épitope: AA 4-19

Fonction: Anti-p40 [14D5E8F12], Mouse IgG1, kappa

Specificité: This antibody is specific for the p40 peptide of the human p63. P63 protein acts as a sequence specific DNA binding transcriptional activator or repressor. It is also involved in notch signaling by probably inducing JAG1 and JAG2 and plays a role in the regulation of epithelial morphogenesis. The p63 Molecule has a high degree of structural homology with p53 and has three similar functional domains: N-terminal transcription activation region, core DNA binding region, and C-terminal oligomerization region.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing mice with p40 peptide comprising amino acids 4-19 (LENNAQTQFSEPQYTN) of the p63 protein (Uniprot -Q9H3D4). The p40 peptide had a sulfhydryl group at its N-terminus and a carrier protein KLH to improve its immunogenicity.

Isotype: IgG1 kappa

Information d'application

Indications d'application: This antibody is highly similar to commercially available rabbit antibody ZR8 in immunohistochemical staining of p40. This antibody does not stain lung adenocarcinoma but positively stains lung squamous cell carcinoma. This antibody can used for the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma via immunohistochemical staining. This binding specificity and affinity of this antibody was determined using ELISA. The original IgG1 antibody is reported to bind human p40 with an affinity constant of 5.99 X 10^9 M^(-1) (CN104447994).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: p40 (p63 Delta)

Autre désignation: p40

Sujet: TP63, CUSP, Tumor protein 63, chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p73L, p40, p51, ZR8

UniProt: Q9H3D4