Recombinant Cytokeratin 18 anticorps (Extracellular Domain)

N° du produit ABIN7543320

L’anticorps Lapin Chimeric anti-Cytokeratin 18 a été validé pour ELISA. Il convient pour détecter Cytokeratin 18 dans des échantillons de Humain.

Aperçu rapide pour Recombinant Cytokeratin 18 anticorps (Extracellular Domain) (ABIN7543320)

Antigène: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp Cytokeratin 18 est non-conjugé

Application: ELISA

Clone: HH156

Détail du produit anti-Cytokeratin 18 anticorps

Épitope: Extracellular Domain

Fonction: Anti-Cytokeratin 18 [HH156], Rabbit IgG, kappa

Specificité: This antibody is specific for extracellular domain of the human cytokeratin 18 containing amino acids 'LEDGEDFNLGDALD'. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 18 is widely expressed in human monolayer epithelial tissues, and generally appears in pairs with CK8. CK18 is a serum marker for a variety of tumor diagnosis, as well as a serum marker for liver injury. It is involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, it plays a role in filament reorganization. It is also involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with human cytokeratin 18 extracellular domain polypeptide 'LEDGEDFNLGDALD'. Later on the humanized version of this antibody was generated by grafting the CDRs of the original mouse antibody E156 onto human framework regions.

Isotype: IgG kappa

Information d'application

Indications d'application: This antibody can bind human cytokeratin 18 in an ELISA. The original IgG1 version of this antibody is reported to bind human cytokeratin 18 with a binding affinity of 32.8 pM.

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Cytokeratin 18

Antigène: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Autre désignation: Cytokeratin 18

Sujet: CK18, CK-18, CK 18, KRT18, CYK18, Keratin type I cytoskeletal 18, Cytokeratin-18, Cell proliferation-inducing gene 46 protein

UniProt: P05783

Pathways: Apoptose, Caspase Cascade in Apoptosis