Recombinant beta Catenin anticorps

N° du produit ABIN7543332

L’anticorps Lapin Chimeric anti-beta Catenin a été validé pour IHC et ELISA. Il convient pour détecter beta Catenin dans des échantillons de Humain.

Aperçu rapide pour Recombinant beta Catenin anticorps (ABIN7543332)

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp beta Catenin est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: 3B1D11A8

Détail du produit anti-beta Catenin anticorps

Fonction: Anti-B-catenin [3B1D11A8], Rabbit IgG, kappa

Specificité: This antibody binds human beta-catenin. The human β-catenin acts as a multi-functional protein that plays a very important role in cell adhesion and Wnt signaling pathway mediated gene expression regulation. Β-catenin on the cell membrane can be combined with the cytoplasmic domain of E-Cadherin (E-CAD) to form an e-cadherin / β-catenin complex, which mediates mutual adhesion between the same type. It acts as a key regulatory molecule in the Wnt signaling pathway and plays an important role in the occurrence / evolution of the embryonic development and tumor.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with human beta-catenin-KLH conjugate in Freund's non-complete adjuvant.

Isotype: IgG kappa

Information d'application

Indications d'application: The binding characterization of this antibody was done using ELISA. The original mouse IgG1 antibody binds human B-catenin with an affinity constant of 4.96 X 10^(9) M^(-1). This antibody was also used in the immunohistochemical analysis of colorectal carcinoma and pancreatic cancer tissues. The immunohistochemical staining pattern of this antibody is similar to commercially available antibody CAT-5H10 (CN112457400).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur beta Catenin

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation: B-catenin

Sujet: CTNNB1, CTNNB, Catenin beta-1, Beta-catenin, CAT-5H10, CGMCC No. 19685

UniProt: P35222

Pathways: Peptide Hormone Metabolism