Recombinant IDO1 anticorps

N° du produit ABIN7543333

Cet anticorps anti-IDO1 est un anticorps Souris Monoclonal détectant IDO1 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour Recombinant IDO1 anticorps (ABIN7543333)

Antigène: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IDO1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 19C5

Détail du produit anti-IDO1 anticorps

Fonction: Anti-IDO1 [19C5], Mouse IgG1, kappa

Specificité: This antibody binds an enzyme called indoleamine 2,3-dioxygenase 1 (IDO1). This molecule catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. It is involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. It acts as a suppressor of anti-tumor immunity. IDO1 is the target for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation. Elevated IDO1 expression is a hallmark of major viral and bacterial infections.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing mice with recombinant human IDO1 protein.

Isotype: IgG1 kappa

Information d'application

Indications d'application: This antibody can bind human IDO1 in an ELISA. The original mouse IgG1 antibody binds human IDO1 with an affinity constant of 7.68 X 10^(9) M^(-1). This antibody can be used for the immunohistochemical analysis of various normal and cancerous human tissues like lymph node cells and Hodgkin's lymphoma tissues. The immunohistochemical staining pattern of this antibody is similar to another anti-IDO1 antibody EPR20374 (CN113045667).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur IDO1

Antigène: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Autre désignation: IDO1

Sujet: IDO-1, IDO, INDO, Indoleamine 2 3-dioxygenase 1, Indoleamine-pyrrole 2 3-dioxygenase, CGMCC NO 20770, EPR20374

UniProt: P14902

Pathways: Activated T Cell Proliferation