AVPR1A anticorps (C-Term, Intracellular)

N° du produit ABIN7581828

Cet anticorps anti-AVPR1A Polyclonal Cobaye (ABIN7581828) détecte spécifiquement AVPR1A dans WB et IHC. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour AVPR1A anticorps (C-Term, Intracellular) (ABIN7581828)

Antigène: AVPR1A (Arginine Vasopressin Receptor 1A (AVPR1A))

Reactivité: Rat

Hôte: Cobaye

Clonalité: Polyclonal

Conjugué: Cet anticorp AVPR1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-AVPR1A anticorps

Épitope: AA 378-390, C-Term, Intracellular

Fonction: A Guinea Pig Polyclonal Antibody to Vasopressin V1A Receptor (AVPR1A)

Séquence: (C)KFAKDDSDSM SRR

Homologie: Mouse - identical, human - 10 out of 13 amino acid residues identical

Attributs du produit: Guinea Pig Anti-Vasopressin V1A Receptor (AVPR1A) Antibody (ABIN7581828) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize V1aR from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-Vasopressin V1A Receptor (AVPR1A) Antibody (ABIN7042946, ABIN7045335 and ABIN7045336) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KFAKDDSDSMSRR, corresponding to amino acid residues 378-390 of rat AVPR1A 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234786)

Blocking Peptide: (ABIN7234786)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur AVPR1A

Antigène: AVPR1A (Arginine Vasopressin Receptor 1A (AVPR1A))

Autre désignation: AVPR1A

Sujet:

Synonyms: V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor

Description: Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonapeptide involved in the homeostasis of body fluid, blood volume, vascular tone, and blood pressure. AVP also belongs to the family of vasoactive and mitogenic peptides involved in physiological and pathological cell growth and differentiation1.AVP exerts its actions through binding to specific V1A, V1B, and V2, membrane receptors coupled to distinct second messengers2. V1 AVP receptor has the typical features of a G-protein coupled transmembrane receptor with seven putative hydrophobic domains, connected by three extracellular and three intracellular loops3.V1 receptors activate phospholipases A2, C, and D, resulting in the production of inositol 1,4,5-trisphosphate (IPS) and 1,Z-diacylglycerol (DAG), the mobilization of intracellular Ca2+, the influx of extracellular Ca2+, the activation of protein kinase C, and protein phosphorylation4. V1A AVP receptors have been shown by radioligand binding techniques to be present in vascular smooth muscle cells, hepatocytes, blood platelets, lymphocytes and monocytes, type 2 pneumocytes, adrenal cortex, brain (hippocampus septum et amygdalae), reproductive organs, retinal epithelium, renal mesangial cells, and the A10, A7r5,3T3, and WRK-1 cell lines4. V1A AVP receptors mediate cell contraction and proliferation, platelet aggregation, coagulation factor release, and glycogenolysis. V1B AVP receptors are located in the anterior pituitary where they stimulate ACTH release1.

ID gène: 25107

UniProt: P30560

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Response to Water Deprivation, Regulation of Carbohydrate Metabolic Process