BST1 anticorps (Extracellular, N-Term)

N° du produit ABIN7581832

Cet anticorps Lapin Polyclonal détecte spécifiquement BST1 dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour BST1 anticorps (Extracellular, N-Term) (ABIN7581832)

Antigène: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BST1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-BST1 anticorps

Épitope: AA 129-144, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to C3aR1 (extracellular)

Séquence: (C)KVGDFLSW(S)RQENASG

Homologie: Mouse,Rat - 15 out of 16 amino acid residues identical Not recommended for BST1 from human samples

Attributs du produit: Anti-CD157/BST1 (extracellular) Antibody (ABIN7581832) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize CD157 from mouse and rat samples. The antibody is not recommended for work with human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KVGDFLSW(S)RQENASG, corresponding to amino acid residues 129 - 144 of mouse BST1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1000

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur BST1

Antigène: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Autre désignation: BST1 

Sujet:

Synonyms: Bone Marrow Stromal Antigen 1, BST-1, ADP-Ribosyl Cyclase 2, Cyclic ADP-ribose hydrolase 2, CADPr Hydrolase 2, CADPR2, LY-65

Description: CD157, also known as bone marrow stromal cell antigen 1 (BST1), is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein with a dual function as a receptor and a β-NAD+-metabolizing ectoenzyme of the ADP-ribosyl cyclases gene family1.CD157 and its paralog CD38, catalyze the formation of cyclic ADP-ribose (cADPR) from NAD, a second messenger involved in intracellular calcium mobilization through ryanodine receptors, among other functions 1,2.As a receptor, CD157 interacts with β1 and β2 integrins (CD29 and CD18 respectively) to form a multimolecular complex that mediates intracellular signaling through the FAK/Src pathway 1-3. Known ligands for CD157 include extracellular matrix components like fibronectin, fibrinogen, laminin-1 and type 1 collagen 2,3.As it name suggests, CD157 was first identified in bone marrow-derived cells, but it is also expressed in other immune system cells like neutrophils, T-cells, pre B-cells and macrophages. CD157 has been demonstrated to be involved in both the innate and adaptive immune response with roles in B- and T-cell growth and the control of myeloid cells migration during inflammation 1.CD157 is considered a marker and therapeutic target for several hematological malignancies like acute myeloid leukemia (AML) as well as several solid tumors like ovarian and malignant mesothelioma 3,4,5.Outside the immune system, CD157 is expressed in vascular endothelium, intestine and brain among others. Interestingly, CD157, has been identified as a risk factor for neurodegenerative diseases, particularly Parkinson's disease 2,6. The exact role of CD157 in the nervous system is not clear, but it appears to have a role in neurogenesis and neural stem cells proliferation, as well as a role in neuroinflammation probably through its association with CD18 and CD11b 2,7.Finally, studies with CD157 knockout mice, reveal its involvement in depression-like behaviors, social avoidance and anxiety disorders 2,8.

ID gène: 12182

UniProt: Q64277