SHANK2 anticorps (AA 84-309) (FL490)

N° du produit ABIN7595471

Cet anticorps Souris Monoclonal détecte spécifiquement SHANK2 dans IHC et ICC. Il présente une réactivité envers Rat.

Aperçu rapide pour SHANK2 anticorps (AA 84-309) (FL490) (ABIN7595471)

Antigène: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SHANK2 est conjugé à/à la FL490

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N23B-6

Détail du produit anti-SHANK2 anticorps (FL490)

Épitope: AA 84-309

Fonction: Anti-Shank2 Antibody FL490 Conjugate

Specificité: No off-targets reported for Shank1 or Shank3

Réactivité croisée: Humain, Souris, Lapin, Rat

Attributs du produit:

Description: Our Anti-Shank2 mouse monoclonal primary antibody is produced in-house from hybridoma clone N23B/6. It detects human, mouse, and rat Shank2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Shank2 mouse monoclonal primary antibody from hybridoma clone N23B/6. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Pureté: > 90 % specific antibody

Immunogène: Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (accession number Q9QX74) produced recombinantly in E. Coli

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Date de péremption: 12 months

Détails sur SHANK2

Antigène: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Autre désignation: Shank2

Sujet:

Synonyms: SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3)

Target Description: SH3 and multiple ankyrin repeat domains protein 2, or shank 2 is a member of the shank family. Shank 2 binding domains include a SH3 domain, a proline rich domain, and a PDZ domain. Shank 2 is found in kidney, liver tissue, and epithelial cells. In brain, Shank 2 is expressed at the apical cell membrane, cytoplasm, synapse, postsynaptic density, growth cone, and dendritic spine. Some isoforms of shank 2 are expressed during development, while others are expressed in mature tissue. Shank 2 acts as a scaffold protein anchoring and connecting membrane bound receptors, including NMDA and glutamate receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 2 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 2 gene have been associated with autism spectrm disorder and blount disease.

Gene Name Alternatives: Shank2 Cortbp1

Poids moléculaire: 160 kDa