SHANK2 anticorps (AA 84-309)

N° du produit ABIN863120

Détail du produit anti-SHANK2 anticorps

Antigène: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Épitope: AA 84-309

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SHANK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)

Specificité: Detects ~160 kDa. Recognizes Shank1, 2 and 3.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 84-309 of rat Shank2

Clone: N23b-49 (Formerly S23b-49)

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN863120 was sufficient for detection of Shank1-4 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Références pour anticorps anti-SHANK2 (ABIN863120)

Nagura, Ishikawa, Kobayashi, Takao, Tanaka, Nishikawa, Tamura, Shiosaka, Suzuki, Miyakawa, Fujiyoshi, Doi et al.: "Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 ..." dans: Molecular brain, Vol. 5, pp. 43, (2013) (PubMed).

Détails sur SHANK2

Antigène: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Autre désignation: SHANK (SHANK2 Produits)

Synonymes: anticorps AUTS17, anticorps CORTBP1, anticorps CTTNBP1, anticorps ProSAP1, anticorps SHANK, anticorps SPANK-3, anticorps mKIAA1022, anticorps auts17, anticorps cortbp1, anticorps cttnbp1, anticorps prosap1, anticorps spank-3, anticorps shank2, anticorps MGC122482, anticorps CortBP1, anticorps Spank-3, anticorps SHANK2, anticorps SH3 and multiple ankyrin repeat domains 2, anticorps SH3 and multiple ankyrin repeat domains 2 L homeolog, anticorps SH3 and multiple ankyrin repeat domains protein 2, anticorps SHANK2, anticorps Shank2, anticorps shank2.L, anticorps shank2, anticorps LOC100438523

Sujet: Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).

ID gène: 171093

UniProt: Q9QX74