DLG4 anticorps (AA 77-299) (FL594)

N° du produit ABIN7595732

Cet anticorps Souris Monoclonal détecte spécifiquement DLG4 dans IHC et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour DLG4 anticorps (AA 77-299) (FL594) (ABIN7595732)

Antigène: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DLG4 est conjugé à/à la FL594

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: K28-43

Détail du produit anti-DLG4 anticorps (FL594)

Épitope: AA 77-299

Fonction: Anti-PSD-95 Antibody FL594 Conjugate

Specificité: No off-targets reported for recombinant Chapsyn-110, SAP97 or SAP102

Réactivité croisée: Poulet, Humain, Souris, Non-Human Primate, Rat

Attributs du produit:

Description: Our Anti-PSD 95 mouse monoclonal primary antibody is produced in-house from hybridoma clone K28/43. It is KO validated, detects chicken, human, mouse, non-human primate, and rat PSD 95, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our PSD 95 mouse monoclonal primary antibody from hybridoma clone K28/43. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Pureté: > 90 % specific antibody

Immunogène: Fusion protein amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (accession number P78352) produced recombinantly in E. Coli

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Date de péremption: 12 months

Détails sur DLG4

Antigène: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Autre désignation: PSD 95

Sujet:

Synonyms: Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

Target Description: PSD-95 is a member of the MAGUK (membrane associated guanylate kinase) family (which also includes PSD-93, SAP97 and SAP102) and functions as a scaffold protein that can cluster membrane receptors, ion channels, including NMDA receptor subunits, Kv1 potassium channels and Caspr2. The protein is encoded by DLG4, contains hallmark PDZ, SH3 and GuK domains and is found at post synaptic densities where it plays an important role in the formation and maintenance of synaptic junctions (Zhou and Blumberg, 2003). Indeed, overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Antibodies against PSD95/DLG4 are frequently used in conjunction with pre-synaptic markers to localize synapses by microscopy

Gene Name Alternatives: DLG4 PSD95

Poids moléculaire: 95-110 kDa (varies with cell background due to phosphorylation)

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity