BAG2 anticorps (AA 1-211)

N° du produit ABIN7599087

Cet anticorps anti-BAG2 est un anticorps Souris Monoclonal détectant BAG2 dans WB et FACS. Adapté pour Humain et Souris.

Aperçu rapide pour BAG2 anticorps (AA 1-211) (ABIN7599087)

Antigène: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BAG2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 8F11G2

Détail du produit anti-BAG2 anticorps

Épitope: AA 1-211

Fonction: Anti-BAG2 Antibody Picoband® (monoclonal, 8F11G2)

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-BAG2 Antibody Picoband® (monoclonal, 8F11G2) (ABIN7599087). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human BAG2 recombinant protein (Position: M1-N211). Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.

Isotype: IgG1

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 Molecular chaperone regulators". J Biol Chem 274 (2): 781-6. 2. "Entrez Gene: BAG2 BCL2-associated athanogene 2".

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur BAG2

Antigène: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Autre désignation: BAG2

Sujet:

Synonyms: Cofilin-2, Cofilin, muscle isoform, CFL2

Tissue Specificity: Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.

Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

Poids moléculaire: 24 kDa

ID gène: 9532

UniProt: O95816