GSDMD anticorps (AA 1-484)

N° du produit ABIN7599431

L’anticorps Lapin Polyclonal anti-GSDMD a été validé pour WB, ELISA, IF, IHC, ICC et FACS. Il convient pour détecter GSDMD dans des échantillons de Humain.

Aperçu rapide pour GSDMD anticorps (AA 1-484) (ABIN7599431)

Antigène: GSDMD (Gasdermin D (GSDMD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSDMD est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-GSDMD anticorps

Épitope: AA 1-484

Fonction: Anti-GSDMD Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-GSDMD Antibody Picoband® (ABIN7599431). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GSDMD recombinant protein (Position: M1-H484).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ruhl, S., Shkarina, K., Demarco, B., Heilig, R., Santos, J. C., Broz, P. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science 362: 956-960, 2018. 2. Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., Shao, F. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526: 660-665, 2015. 3. Zhu, Q., Zheng, M., Balakrishnan, A., Karki, R., Kanneganti, T.-D. Gasdermin D promotes AIM2 inflammasome activation and is required for host protection against Francisella novicida. J. Immun. 201: 3662-3668, 2018.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur GSDMD

Antigène: GSDMD (Gasdermin D (GSDMD))

Autre désignation: GSDMD

Sujet:

Synonyms: gasdermin D, gasdermin-D

Tissue Specificity: Brain, placental, and gut tissues.

Background: Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.

Poids moléculaire: 30, 53 kDa

ID gène: 79792

UniProt: P57764

Pathways: Inflammasome