TMPRSS6 anticorps (AA 1-759)

N° du produit ABIN7599541

Cet anticorps Lapin Polyclonal détecte spécifiquement TMPRSS6 dans WB, ELISA et FACS. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour TMPRSS6 anticorps (AA 1-759) (ABIN7599541)

Antigène: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMPRSS6 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-TMPRSS6 anticorps

Épitope: AA 1-759

Fonction: Anti-Matriptase 2/TMPRSS6 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Matriptase 2/TMPRSS6 Antibody Picoband® (ABIN7599541). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Matriptase 2/TMPRSS6 recombinant protein (Position: M1-Q759).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088-1092, 2008. 2. Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydinok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., Andrews, N. C., Fleming, M. D. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nature Genet. 40: 569-571, 2008. 3. Guillem, F., Kannengiesser, C., Oudin, C., Lenoir, A., Matak, P., Donadieu, J., Isidor, B., Mechinaud, F., Aguilar-Martinez, P., Beaumont, C., Vaulont, S., Grandchamp, B., Nicolas, G. Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity. Hum. Mutat. 33: 1388-1396, 2012.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur TMPRSS6

Antigène: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Autre désignation: TMPRSS6

Sujet:

Synonyms: Protein sprouty homolog 2, Spry-2, SPRY2

Tissue Specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.

Background: Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 90 kDa, 95 kDa

ID gène: 164656

Pathways: Transition Metal Ion Homeostasis