ARNTL anticorps (AA 116-447)

N° du produit ABIN7599774

L’anticorps Lapin Polyclonal anti-ARNTL a été validé pour WB et ELISA. Il convient pour détecter ARNTL dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ARNTL anticorps (AA 116-447) (ABIN7599774)

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARNTL est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ARNTL anticorps

Épitope: AA 116-447

Fonction: Anti-BMAL1/ARNTL Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-BMAL1/ARNTL Antibody Picoband® (ABIN7599774). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human BMAL1/ARNTL recombinant protein (Position: R116-E447).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Hatanaka F, Matsubara C, Myung J, Yoritaka T, Kamimura N, Tsutsumi S, Kanai A, Suzuki Y, Sassone-Corsi P, Aburatani H, Sugano S,Takumi T (Dec 2010). "Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism". Molecular and Cellular Biology. 30 (24): 5636-5648. 2. Pappa KI, Gazouli M, Anastasiou E, Iliodromiti Z, Antsaklis A, Anagnou NP (Feb 2013). "The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus". Diabetes Research and Clinical Practice. 99 (2): 151-7. 3. Richards J, Diaz AN, Gumz ML (Oct 2014). "Clock genes in hypertension: novel insights from rodent models". Blood Pressure Monitoring. 19 (5): 249-54.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur ARNTL

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Autre désignation: ARNTL

Sujet:

Synonyms: Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, bHLHe5, Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3, ARNTL, BHLHE5, BMAL1, MOP3, PASD3

Tissue Specificity: Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.

Background: Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 75 kDa

ID gène: 406

UniProt: O00327

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, L'effet Warburg