CDK5RAP2 anticorps (AA 168-1878)

N° du produit ABIN7600238

Cet anticorps anti-CDK5RAP2 est un anticorps Lapin Polyclonal détectant CDK5RAP2 dans ELISA, WB, IF et ICC. Adapté pour Humain.

Aperçu rapide pour CDK5RAP2 anticorps (AA 168-1878) (ABIN7600238)

Antigène: CDK5RAP2 (CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK5RAP2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-CDK5RAP2 anticorps

Épitope: AA 168-1878

Fonction: Anti-CDK5RAP2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-CDK5RAP2 Antibody Picoband® (ABIN7600238). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CDK5RAP2 recombinant protein (Position: E168-P1878).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bond, J., Roberts, E., Springell, K., Lizarraga, S., Scott, S., Higgins, J., Hampshire, D. J., Morrison, E. E., Leal, G. F., Silva, E. O., Costa, S. M. R., Baralle, D., Raponi, M., Karbani, G., Rashid, Y., Jafri, H., Bennett, C., Corry, P., Walsh, C. A., Woods, C. G. A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nature Genet. 37: 353-355, 2005. Note: Erratum: Nature Genet. 37: 555 only, 2005. 2. Ching, Y. P., Qi, Z., Wang, J. H. Cloning of three novel neuronal Cdk5 activator binding proteins. Gene 242: 285-294, 2000. 3. Evans, P. D., Vallender, E. J., Lahn, B. T. Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. Gene 375: 75-79, 2006.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur CDK5RAP2

Antigène: CDK5RAP2 (CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2))

Autre désignation: CDK5RAP2

Sujet:

Synonyms: NADPH oxidase 5, NOX5

Tissue Specificity: Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).

Background: CDK5 regulatory subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene. This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 250 kDa

ID gène: 55755

Pathways: M Phase, SARS-CoV-2 Protein Interactome