RORB anticorps (AA 236-470)

N° du produit ABIN7600788

Cet anticorps Lapin Polyclonal détecte spécifiquement RORB dans WB, ELISA et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour RORB anticorps (AA 236-470) (ABIN7600788)

Antigène: RORB (RAR-Related Orphan Receptor B (RORB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RORB est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-RORB anticorps

Épitope: AA 236-470

Fonction: Anti-ROR beta/RORB Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-ROR beta/RORB Antibody Picoband® (ABIN7600788). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ROR beta/RORB recombinant protein (Position: E236-K470).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Andre, E., Conquet, F., Steinmayr, M., Stratton, S. C., Porciatti, V., Becker-Andre, M. Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 17: 3867-3877, 1998. 2. Baler, R., Coon, S., Klein, D. C. Orphan nuclear receptor RZR-beta: cyclic AMP regulates expression in the pineal gland. Biochem. Biophys. Res. Commun. 220: 975-978, 1996. 3. Carlberg, C., Hooft van Huijsduijnen, R., Staple, J. K., DeLamarter, J. F., Becker-Andre, M. RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Molec. Endocr. 8: 757-770, 1994.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur RORB

Antigène: RORB (RAR-Related Orphan Receptor B (RORB))

Autre désignation: RORB

Sujet:

Synonyms: One cut domain family member 2, Hepatocyte nuclear factor 6-beta, HNF-6-beta, One cut homeobox 2, Transcription factor ONECUT-2, OC-2, ONECUT2, HNF6B

Tissue Specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Background: RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene. The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm.

Poids moléculaire: 53 kDa

ID gène: 6096

UniProt: Q92753

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway