NOS1AP anticorps (AA 24-438)

N° du produit ABIN7600833

Cet anticorps Lapin Polyclonal détecte spécifiquement NOS1AP dans WB, ELISA, IHC et FACS. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour NOS1AP anticorps (AA 24-438) (ABIN7600833)

Antigène: NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOS1AP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-NOS1AP anticorps

Épitope: AA 24-438

Fonction: Anti-CAPON/NOS1AP Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-CAPON/NOS1AP Antibody Picoband® (ABIN7600833). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CAPON/NOS1AP recombinant protein (Position: D24-D438).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Carrel, D., Du, Y., Komlos, D., Hadzimichalis, N. M., Kwon, M., Wang, B., Brzustowicz, L. M., Firestein, B. L. NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway. J. Neurosci. 29: 8248-8258, 2009. 2. Chang, K.-C., Barth, A. S., Sasano, T., Kizana, E., Kashiwakura, Y., Zhang, Y., Foster, D. B., Marban, E. CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc. Nat. Acad. Sci. 105: 4477-4482, 2008. 3. Jaffrey, S. R., Snowman, A. M., Eliasson, M. J. L., Cohen, N. A., Snyder, S. H. CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron 20: 115-124, 1998.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur NOS1AP

Antigène: NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))

Autre désignation: NOS1AP

Sujet:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15, Unph-2, Unph4, USP15, KIAA0529

Tissue Specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Background: Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene. This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms

Poids moléculaire: 60 kDa

ID gène: 9722

UniProt: O75052