PDGFC anticorps (AA 288-345)

N° du produit ABIN7601106

Cet anticorps Lapin Polyclonal détecte spécifiquement PDGFC dans WB, ELISA et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour PDGFC anticorps (AA 288-345) (ABIN7601106)

Antigène: PDGFC (Platelet-Derived Growth Factor C (PDGFC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDGFC est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-PDGFC anticorps

Épitope: AA 288-345

Fonction: Anti-PDGFC Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-PDGFC Antibody Picoband® (ABIN7601106). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PDGFC recombinant protein (Position: L288-G345).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ding, H., Wu, X., Bostrom, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G. Y., Soriano, P., Betsholtz, C., Hart, T. C., Marazita, M. L., Field, L. L., Tam, P. P. L., Nagy, A. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nature Genet. 36: 1111-1116, 2004. 2. Fredriksson, L., Li, H., Fieber, C., Li, X., Eriksson, U. Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23: 3793-3802, 2004. 3. Gilbertson, D. G., Duff, M. E., West, J. W., Kelly, J. D., Sheppard, P. O., Hofstrand, P. D., Gao, Z., Shoemaker, K., Bukowski, T. R., Moore, M., Feldhaus, A. L., Humes, J. M., Palmer, T. E., Hart, C. E. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds PDGF alpha and beta receptor. J. Biol. Chem. 276: 27406-27414, 2001.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur PDGFC

Antigène: PDGFC (Platelet-Derived Growth Factor C (PDGFC))

Autre désignation: PDGFC

Sujet:

Synonyms: NADPH oxidase 5, NOX5

Tissue Specificity: Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).

Background: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

Poids moléculaire: 39 kDa

ID gène: 56034

Pathways: Signalisation RTK, Platelet-derived growth Factor Receptor Signaling