KDM6A anticorps (AA 391-704)

N° du produit ABIN7601589

Cet anticorps Lapin Polyclonal détecte spécifiquement KDM6A dans WB, ELISA, IF, ICC et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour KDM6A anticorps (AA 391-704) (ABIN7601589)

Antigène: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM6A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-KDM6A anticorps

Épitope: AA 391-704

Fonction: Anti-UTX/KDM6A Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-UTX/KDM6A Antibody Picoband® (ABIN7601589). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human UTX/KDM6A recombinant protein (Position: A391-A704).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Agger, K., Cloos, P. A. C., Christensen, J., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E., Helin, K. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449: 731-734, 2007. 2. Chakraborty, A. A., Laukka, T., Myllykoski, M., Ringel, A. E., Booker, M. A., Tolstorukov, M. Y., Meng, Y. J., Meier, S. R., Jennings, R. B., Creech, A. L., Herbert, Z. T., McBrayer, S. K., Olenchock, B. A., Jaffe, J. D., Haigis, M. C., Beroukhim, R., Signoretti, S., Koivunen, P., Kaelin, W. G., Jr. Histone demethylase KDM6A ly senses oxygen to control chromatin and cell fate. Science 363: 1217-1222, 2019. 3. Faralli, H., Wang, C., Nakka, K., Benyoucef, A., Sebastian, S., Zhuang, L., Chu, A., Palii, C. G., Liu, C., Camellato, B., Brand, M., Ge, K., Dilworth, F. J. UTX demethylase activity is required for satellite cell-mediated muscle regeneration. J. Clin. Invest. 126: 1555-1565, 2016.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur KDM6A

Antigène: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Autre désignation: KDM6A

Sujet:

Synonyms: Hepatic leukemia factor, HLF

Tissue Specificity: Highly expressed in liver, lower levels in lung and kidney.

Background: Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene.

Poids moléculaire: 154 kDa

ID gène: 7403

UniProt: O15550

Pathways: Tube Formation, L'effet Warburg