IL-37 anticorps (AA 46-218)

N° du produit ABIN7601794

L’anticorps Lapin Polyclonal anti-IL-37 a été validé pour IHC, ELISA, ICC, IF et FACS. Il convient pour détecter IL-37 dans des échantillons de Humain.

Aperçu rapide pour IL-37 anticorps (AA 46-218) (ABIN7601794)

Antigène: IL-37 (IL37) (Interleukin 37 (IL37))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-37 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-IL-37 anticorps

Épitope: AA 46-218

Fonction: Anti-IL37 Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-IL37 Antibody Picoband® (ABIN7601794). Tested in ELISA, Flow Cytometry, IF, IHC, ICC applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human IL37 recombinant protein (Position: V46-D218).

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ballak, D. B., Li, S., Cavalli, G., Stahl, J., Tengesdal, I. W., van Diepen, J. A., Kluck, V., Swartzwelter, B., Azam, T., Tack, C. J., Stienstra, R., Mandrup-Poulsen, T., Seals, D. R., Dinarello, C. A. Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue. J. Biol. Chem. 293: 14224-14236, 2018. 2. Busfield, S. J., Comrack, C. A., Yu, G., Chickering, T. W., Smutko, J. S., Zhou, H., Leiby, K. R., Holmgren, L. M., Gearing, D. P., Pan, Y. Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. Genomics 66: 213-216, 2000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur IL-37

Antigène: IL-37 (IL37) (Interleukin 37 (IL37))

Autre désignation: IL37

Sujet:

Synonyms: Protocadherin-15, PCDH15, USH1F

Tissue Specificity: Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited pattern of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed.

Background: Interleukin 37 (IL-37), also known as IL-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine. Interleukines are cytokines that make an important part of immune signaling. It belongs to the interleukin-1 family. This protein is in humans encoded by the IL37 gene located on the chromosome 2. The mechanism of IL-37 functions is still to be elucidated. IL-37 possesses not only anti-inflmammatory effects but it is also important in antimicrobial response or antitumor immunity. The IL-37 acts intracellulary and extracellulary.

Poids moléculaire: 180 kDa

ID gène: 27178