ECD/SGT1 anticorps (AA 50-632)

N° du produit ABIN7601917

L’anticorps Lapin Polyclonal anti-ECD/SGT1 a été validé pour WB, ELISA et FACS. Il convient pour détecter ECD/SGT1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ECD/SGT1 anticorps (AA 50-632) (ABIN7601917)

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ECD/SGT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-ECD/SGT1 anticorps

Épitope: AA 50-632

Fonction: Anti-SGT1/ECD Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-SGT1/ECD Antibody (ABIN7601917). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ECD recombinant protein (Position: L50-N632).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur ECD/SGT1

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Autre désignation: ECD

Sujet:

Synonyms: Disintegrin and metalloproteinase domain-containing protein 10, ADAM 10, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c, ADAM10, KUZ, MADM

Tissue Specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.

Background: Protein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

Poids moléculaire: 73 kDa

ID gène: 11319

UniProt: O95905

Pathways: Regulation of Carbohydrate Metabolic Process