Oncostatin M anticorps (AA 55-158)

N° du produit ABIN7602011

Cet anticorps anti-Oncostatin M Polyclonal Lapin (ABIN7602011) détecte spécifiquement Oncostatin M dans WB et ELISA. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Oncostatin M anticorps (AA 55-158) (ABIN7602011)

Antigène: Oncostatin M (OSM)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Oncostatin M anticorps

Épitope: AA 55-158

Fonction: Anti-Osm Antibody

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Rat Osm shares 46%,71.2% amino acid (aa) sequence identity with human,mouse Osm,respectively.

Attributs du produit: Anti-Osm Antibody. Tested in WB, ELISA applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived rat Osm recombinant protein (Position: E55-D158). Rat Osm shares 46% and 71.2% amino acid (aa) sequence identity with human and mouse Osm, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat ELISA, 0.1-0.5 μg/mL, Rat

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Oncostatin M

Antigène: Oncostatin M (OSM)

Autre désignation: Osm

Sujet:

Background: OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Gene Full Name: oncostatin M

Poids moléculaire: 27 kDa

ID gène: 289747

UniProt: Q65Z15

Pathways: Signalistation JAK/STAT, Negative Regulation of Hormone Secretion