OS9 anticorps (AA 56-635)

N° du produit ABIN7602048

Cet anticorps Lapin Polyclonal détecte spécifiquement OS9 dans WB, ELISA, ICC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour OS9 anticorps (AA 56-635) (ABIN7602048)

Antigène: OS9 (Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OS9 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-OS9 anticorps

Épitope: AA 56-635

Fonction: Anti-OS9 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-OS9 Antibody Picoband® (ABIN7602048). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human OS9 recombinant protein (Position: Q56-E635).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Baek, J. H., Mahon, P. C., Oh, J., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J., Semenza, G. L. OS-9 interacts with hypoxia-inducible factor 1-alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1-alpha. Molec. Cell 17: 503-512, 2005. 2. Bhamidipati, A., Denic, V., Quan, E. M., Weissman, J. S. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Molec. Cell 19: 741-751, 2005. 3. Friedmann, E., Salzberg, Y., Weinberger, A., Shaltiel, S., Gerst, J. E. YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J. Biol. Chem. 277: 35274-35281, 2002.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur OS9

Antigène: OS9 (Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9))

Autre désignation: OS9

Sujet:

Synonyms: Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, Erf1, Protein Cl1, TB3-1, ETF1, ERF1, RF1, SUP45L1

Tissue Specificity: Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.

Background: Protein OS-9 is a protein that in humans is encoded by the OS9 gene. This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Poids moléculaire: 83 kDa

ID gène: 10956

UniProt: Q13438

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome