Retinoic Acid Receptor alpha anticorps (AA 361-462)

N° du produit ABIN726860

Détail du produit anti-Retinoic Acid Receptor alpha anticorps

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Épitope: AA 361-462

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoic Acid Receptor alpha est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Rat

Homologie: Mouse

Purification: Purified by Protein A.

Immunogène: OVA conjugated synthetic peptide derived from mouse Retinoic acid Receptor Alpha

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Retinoic Acid Receptor alpha

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Autre désignation: RAR alpha (RARA Produits)

Synonymes: anticorps NR1B1, anticorps RAR, anticorps Nr1b1, anticorps RARalpha1, anticorps rar-alpha, anticorps etID309833.12, anticorps rara, anticorps rara2a, anticorps zRAR, anticorps zRAR-alpha, anticorps zgc:109797, anticorps nr1b1, anticorps RAR-ALPHA1, anticorps HS-RARa, anticorps fj66e06, anticorps rara2b, anticorps wu:fj66e06, anticorps retinoic acid receptor alpha, anticorps retinoic acid receptor, alpha, anticorps retinoic acid receptor, alpha a, anticorps retinoic acid receptor alpha L homeolog, anticorps retinoic acid receptor, alpha b, anticorps RARA, anticorps Rara, anticorps LOC100136372, anticorps raraa, anticorps rara.L, anticorps rara, anticorps rarab

Sujet:

Synonyms: RAR, Nr1b1, RARalpha1, Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, Rara

Background: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

ID gène: 19401

UniProt: P11416

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins