DKK1 anticorps (AA 73-272)

N° du produit ABIN7602383

Cet anticorps anti-DKK1 est un anticorps Lapin Polyclonal détectant DKK1 dans ELISA et IHC. Adapté pour Rat et Souris.

Aperçu rapide pour DKK1 anticorps (AA 73-272) (ABIN7602383)

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DKK1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-DKK1 anticorps

Épitope: AA 73-272

Fonction: Anti-Dkk1 Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Dkk1 Antibody Picoband® (ABIN7602383). Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Dkk1 recombinant protein (Position: N73-H272).

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Fedi, P., Bafico, A., Soria, A. N., Burgess, W. H., Miki, T., Bottaro, D. P., Kraus, M. H., Aaronson, S. A.Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.J. Biol. Chem. 274: 19465-19472, 1999. 2. Roessler, E., Du, Y., Glinka, A., Dutra, A., Niehrs, C., Muenke, M.The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. Cytogenet. Cell Genet. 89: 220-224, 2000. 3. Tian, E., Zhan, F., Walker, R., Rasmussen, E., Ma, Y., Barlogie, B., Shaughnessy, J. D., Jr.The role of Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.New Eng. J. Med. 349: 2483-2494, 2003.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur DKK1

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Autre désignation: Dkk1

Sujet:

Synonyms: Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1, UNQ492/PRO1008

Tissue Specificity: Placenta.

Background: DKK1, Dickkopf-related protein 1, is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. By genomic sequence analysis, determined that the DKK1 gene contains 4 exons. The DKK1 gene is mapped to 10q11.2 using FISH. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Poids moléculaire: 38 kDa

ID gène: 13380

UniProt: O54908

Pathways: Signalisation WNT, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation