TXNRD1 anticorps (AA 93-326)

N° du produit ABIN7602673

L’anticorps Lapin Polyclonal anti-TXNRD1 a été validé pour WB et ELISA. Il convient pour détecter TXNRD1 dans des échantillons de Humain.

Aperçu rapide pour TXNRD1 anticorps (AA 93-326) (ABIN7602673)

Antigène: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXNRD1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TXNRD1 anticorps

Épitope: AA 93-326

Fonction: Anti-TXNRD1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-TXNRD1 Antibody Picoband® (ABIN7602673). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TXNRD1 recombinant protein (Position: Y93-Y326).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Dammeyer, P., Damdimopoulos, A. E., Nordman, T., Jimenez, A., Miranda-Vizuete, A., Arner, E. S. J. Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1. J. Biol. Chem. 283: 2814-2821, 2008. 2. Gasdaska, J. R., Gasdaska, P. Y., Gallegos, A., Powis, G. Human thioredoxin reductase gene localization to chromosomal position 12q23-q24.1 and mRNA distribution in human tissue. Genomics 37: 257-259, 1996. 3. Gasdaska, P. Y., Gasdaska, J. R., Cochran, S., Powis, G. Cloning and sequencing of a human thioredoxin reductase. FEBS Lett. 373: 5-9, 1995.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur TXNRD1

Antigène: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Autre désignation: TXNRD1

Sujet:

Synonyms: TXNRD1, GRIM12, KDRF, Thioredoxin reductase 1, cytoplasmic, TR, EC 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1

Background: Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.

Poids moléculaire: 65 kDa

ID gène: 7296

UniProt: Q16881

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis