GPBAR1 anticorps (C-Term)

N° du produit ABIN7602825

Cet anticorps Lapin Polyclonal détecte spécifiquement GPBAR1 dans WB. Il présente une réactivité avec des échantillons de Rat et Souris.

Aperçu rapide pour GPBAR1 anticorps (C-Term) (ABIN7602825)

Antigène: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPBAR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GPBAR1 anticorps

Épitope: C-Term

Fonction: Anti-GPCR TGR5/GPBAR1 Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-GPCR TGR5/GPBAR1 Antibody (ABIN7602825). Tested in WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human GPCR TGR5/GPBAR1, which shares 100% and 92.9% amino acid (aa) sequence identity with human and rat GPCR TGR5/GPBAR1, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur GPBAR1

Antigène: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Autre désignation: GPBAR1

Sujet:

Synonyms: Insulin-like growth factor-binding protein 5,IBP-5,IGF-binding protein 5,IGFBP-5,IGFBP5,IBP5,

Tissue Specificity: Osteosarcoma, and at lower levels in liver, kidney and brain.

Background: The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or TGR5 as is a protein that in humans is encoded by the GPBAR1 gene. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

Poids moléculaire: 46-48 kDa

ID gène: 227289

Pathways: Signalisation WNT, Hormone Transport, Sensory Perception of Sound