GPX3 anticorps (C-Term)

N° du produit ABIN7602892

L’anticorps Lapin Polyclonal anti-GPX3 a été validé pour WB. Il convient pour détecter GPX3 dans des échantillons de Souris et Rat.

Aperçu rapide pour GPX3 anticorps (C-Term) (ABIN7602892)

Antigène: GPX3 (Glutathione Peroxidase 3 (Plasma) (GPX3))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPX3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GPX3 anticorps

Épitope: C-Term

Fonction: Anti-GPX3 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-GPX3 Antibody Picoband® (ABIN7602892). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human GPX3. Human GPX3 shares 100% amino acid (aa) sequence identity with both mouse and rat GPX3.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
1. Chambers, I., Frampton, J., Goldfarb, P., Affara, N., McBain, W., Harrison, P. R. The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J. 5: 1221-1227, 1986. 2. Chu, F.-F. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. Cytogenet. Cell Genet. 66: 96-98, 1994. 3. Chu, F.-F., Esworthy, R. S., Doroshow, J. H., Doan, K., Liu, X.-F. Expression of glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. Blood 79: 3233-3238, 1992.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur GPX3

Antigène: GPX3 (Glutathione Peroxidase 3 (Plasma) (GPX3))

Autre désignation: GPX3

Sujet:

Synonyms: GPX3, GPXP, Glutathione peroxidase 3, GPx-3, GSHPx-3, EC 1.11.1.9, Extracellular glutathione peroxidase, Plasma glutathione peroxidase, GPx-P, GSHPx-P

Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Poids moléculaire: 26 kDa

ID gène: 2878

UniProt: P22352

Pathways: Thyroid Hormone Synthesis