KCNJ1 anticorps (N-Term)

N° du produit ABIN7603179

Cet anticorps Lapin Polyclonal détecte spécifiquement KCNJ1 dans WB. Il présente une réactivité envers Rat, Souris et Singe.

Aperçu rapide pour KCNJ1 anticorps (N-Term) (ABIN7603179)

Antigène: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Reactivité: Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNJ1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KCNJ1 anticorps

Épitope: N-Term

Fonction: Anti-KCNJ1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-KCNJ1 Antibody Picoband® (ABIN7603179). Tested in WB applications. This antibody reacts with Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human KCNJ1, which shares 80% amino acid (aa) sequence identity with both mouse and rat KCNJ1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Monkey, Mouse, Rat
1. Derst, C., Konrad, M., Kockerling, A., Karolyi, L., Deschenes, G., Daut, J., Karschin, A., Seyberth, H. W. Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K(+) channel function. Biochem. Biophys. Res. Commun. 230: 641-645, 1997. 2. Derst, C., Wischmeyer, E., Preisig-Muller, R., Spauschus, A., Konrad, M., Hensen, P., Jeck, N., Seyberth, H. W., Daut, J., Karschin, A. A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels. J. Biol. Chem. 273: 23884-23891, 1998. 3. He, G., Wang, H.-R., Huang, S.-K., Huang, C.-L. Intersectin links WNK kinases to endocytosis of ROMK1. J. Clin. Invest. 117: 1078-1087, 2007.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur KCNJ1

Antigène: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Autre désignation: KCNJ1

Sujet:

Synonyms: Protein S100-A10, Calpactin I light chain, Calpactin-1 light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, S100A10, ANX2LG, CAL1L, CLP11

Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 45 kDa

ID gène: 3758

UniProt: P48048