CDK2 anticorps (CF®405S)

N° du produit ABIN7652817

Cet anticorps anti-CDK2 est un anticorps Souris Monoclonal détectant CDK2 dans WB. Adapté pour Humain, Souris et Xenopus laevis.

Aperçu rapide pour CDK2 anticorps (CF®405S) (ABIN7652817)

Antigène: CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

Reactivité: Humain, Souris, Xenopus laevis

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK2 est conjugé à/à la CF®405S

Application: Western Blotting (WB)

Clone: AN4-3

Détail du produit anti-CDK2 anticorps (CF®405S)

Fonction: Cdk2 / p34cdc2 Serine-Threonine Kinase(AN4.3), CF405S conjugate

Attributs du produit: In vertebrates, as in yeast, multiple cyclins have been identified, including a total of eight such regulatory proteins in mammals. In contrast to the situation in yeast, the Cdc2 p34 kinase is not the only catalytic subunit identified in vertebrates that can interact with cyclins. While Cdc2 p34 is essential for the G2 to M transition in vertebrate cells, a second Cdc2-related kinase has also been implicated in cell cycle control. This protein, designated cyclindependent kinase 2 (Cdk2), also binds to cyclins and its kinase activity is temporally regulated during the cell cycle. Several additional Cdc2-related cyclin dependent kinases have been identified. These include Cdk3, Cdk4, Cdk5, PCTAIRE-1, PCTAIRE-2, PCTAIRE-3, Cdk6 Cdk7, Cdk8 and KKIALRE. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human Cdk2 protein

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Inhibits activation of p34cdc2 kinase by cyclins, Immunoprecipitation, Kinase Assay, Western blot, Flow cytometry: 1-2 μg/mL, Optimal dilution for a specific application should be determined.

Commentaires:

Positive Control: HeLa cells. HeLa whole cell lysate.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur CDK2

Antigène: CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

Autre désignation: Cdk2

Sujet:

Synonyms: Cdc2 related protein kinase, CDC28, CDC2A, CDK1, CDK2, CDKN2, Cell devision kinase 2, Cell division protein kinase 2, cyclin dependent kinase 2 alpha, kinase Cdc2, MPF, p33 protein kinase

Gene Symbol: CDK2

Poids moléculaire: 34 kDa

ID gène: 1017

UniProt: P24941

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA