Recombinant PTH anticorps (AA 1-34) (CF®640R)

N° du produit ABIN7658478

Cet anticorps anti-PTH est un anticorps Souris Monoclonal détectant PTH dans IHC et IHC (fp). Adapté pour Humain, Rat, Porc, Boeuf (Vache), Chien, Cerf, Orang-Utan et Lapin.

Aperçu rapide pour Recombinant PTH anticorps (AA 1-34) (CF®640R) (ABIN7658478)

Antigène: PTH (Parathyroid Hormone (PTH))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Porc, Boeuf (Vache), Chien, Cerf, Orang-Utan, Lapin

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PTH est conjugé à/à la CF®640R

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: RPTH-911

Détail du produit anti-PTH anticorps (CF®640R)

Épitope: AA 1-34

Fonction: Parathyroid Hormone (PTH) (N-Terminal)(rPTH/911), CF640R conjugate

Attributs du produit: Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: A synthetic peptide around amino acids 1-34 of human mature-PTH-polypeptide

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Human parathyroid gland carcinoma

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur PTH

Antigène: PTH (Parathyroid Hormone (PTH))

Autre désignation: Parathyroid Hormone

Classe de substances: Hormone

Sujet:

Synonyms: hPTH, Parathormone, Parathyrin, Parathyroid hormone 1 (PTH1), Parathyroid hormone (PTH)

Gene Symbol: PTH

Poids moléculaire: 9 kDa

ID gène: 5741

UniProt: P01270

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process