Recombinant PTH anticorps (CF®594)

N° du produit ABIN7658501

L’anticorps Lapin Monoclonal anti-PTH a été validé pour IHC et IHC (fp). Il convient pour détecter PTH dans des échantillons de Humain, Rat, Porc, Boeuf (Vache), Chien, Cerf, Orang-Utan, Lapin et Souris.

Aperçu rapide pour Recombinant PTH anticorps (CF®594) (ABIN7658501)

Antigène: PTH (Parathyroid Hormone (PTH))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Porc, Boeuf (Vache), Chien, Cerf, Orang-Utan, Lapin, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PTH est conjugé à/à la CF®594

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: PTH-2295R

Détail du produit anti-PTH anticorps (CF®594)

Fonction: Parathyroid Hormone (PTH) (N-Terminal) (PTH/2295R), CF594 conjugate

Attributs du produit: Epitope of this MAb maps in between aa 1-34. PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Synthetic peptide corresponding to amino acids 1 to 34 of mature PTH conjugated to a carrier

Isotype: IgG

Information d'application

Indications d'application: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunohistology (formalin): 0.25-0.5 μg/mL for 30 minutes at RT. Reactivity with non-human species predicted based on sequence. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user

Commentaires:

Positive Control: Human parathyroid gland carcinoma

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur PTH

Antigène: PTH (Parathyroid Hormone (PTH))

Autre désignation: Parathyroid Hormone

Classe de substances: Hormone

Sujet:

Synonyms: hPTH, Parathormone, Parathyrin, Parathyroid hormone 1 (PTH1), Parathyroid hormone (PTH)

Gene Symbol: PTH

Poids moléculaire: 9 kDa

ID gène: 5741

UniProt: P01270

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process