SREBF2 anticorps (CF®647)

N° du produit ABIN7660436

L’anticorps Souris Monoclonal anti-SREBF2 a été validé pour . Il convient pour détecter SREBF2 dans des échantillons de Humain.

Aperçu rapide pour SREBF2 anticorps (CF®647) (ABIN7660436)

Antigène: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SREBF2 est conjugé à/à la CF®647

Application: Veuillez nous consulter SVP

Clone: SREBP2-1579

Détail du produit anti-SREBF2 anticorps (CF®647)

Fonction: SREBP2(SREBP2/1579), CF647 conjugate

Attributs du produit: The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human SREBF2 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Commentaires:

Positive Control: Ubiqutious expression in adult and fetal tissues. Hep2 or HeLa cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur SREBF2

Antigène: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Autre désignation: SREBP2

Sujet:

Synonyms: AI608257, bHLHd2, Class D basic helix-loop-helix protein 2, OTTHUMP00000028740, Processed sterol regulatory element-binding protein 2, SRBP2_HUMAN, SREBF 2, Srebf2, SREBF2 protein, SREBP 2, SREBP2, SREBP2gc, sterol regulatory element binding factor 2, Sterol regulatory element binding transcription factor 2

Gene Symbol: SREBF2

Poids moléculaire: 68/125 kDa

ID gène: 6721

UniProt: Q12772

Pathways: Regulation of Lipid Metabolism by PPARalpha