ZFYVE28 anticorps (CF®488A)

N° du produit ABIN7662131

L’anticorps Souris Monoclonal anti-ZFYVE28 a été validé pour IHC et IHC (fp). Il convient pour détecter ZFYVE28 dans des échantillons de Humain.

Aperçu rapide pour ZFYVE28 anticorps (CF®488A) (ABIN7662131)

Antigène: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ZFYVE28 est conjugé à/à la CF®488A

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: LST2-2426

Détail du produit anti-ZFYVE28 anticorps (CF®488A)

Fonction: ZFYVE28 (Zinc Finger FYVE-type containing 28)(LST2/2426), CF488A conjugate

Attributs du produit: ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human ZFYVE28 protein

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: PC3 cells. Testis, Brain, Colon, Kidney or Stomach.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur ZFYVE28

Antigène: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Autre désignation: ZFYVE28

Sujet:

Synonyms: Lateral signaling target protein 2 homolog, LST2, LYST2, Zinc finger FYVE domain-containing protein 28 (ZFYVE28)

Gene Symbol: ZFYVE28

Poids moléculaire: 96 kDa

ID gène: 57732

Pathways: EGFR Signaling Pathway