IL6RA anticorps

N° du produit ABIN7670672

Cet anticorps Chèvre Polyclonal détecte spécifiquement IL6RA dans ELISA. Il présente une réactivité envers Souris.

Aperçu rapide pour IL6RA anticorps (ABIN7670672)

Antigène: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Reactivité: Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IL6RA est non-conjugé

Application: ELISA

Détail du produit anti-IL6RA anticorps

Fonction: IL-6R alpha Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogène: Recombinant Mouse IL-6R alpha ra Protein expressed by Mammalian

Isotype: IgG

Information d'application

Indications d'application: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Date de péremption: 12 months

Détails sur IL6RA

Antigène: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Autre désignation: IL-6R alpha

Sujet: InterLeukin-6 receptor subunit aLpha,IL-6 receptor subunit aLpha,IL-6R subunit aLpha,IL-6R-aLpha,IL-6RA,IL-6R 1,Part of the receptor for interleukin 6. Binds to Il6 with low affinity,but does not transduce a signal. Signal activation necessitate an association with Il6ST. Activation leads to the regulation of the immune response,acute-phase reactions and hematopoiesis. The interaction with membrane-bound Il6R and Il6ST stimulates 'classic signaling',the restricted expression of the Il6R limits classic Il6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of Il6 and soluble Il6R to Il6ST stimulates 'trans-signaling'. Alternatively,'cluster signaling' occurs when membrane-bound Il6:Il6R complexes on transmitter cells activate Il6ST receptors on neighboring receiver cells.

UniProt: P22272

Pathways: Signalistation JAK/STAT, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints