NUMA1 anticorps

N° du produit ABIN7670701

Cet anticorps anti-NUMA1 est un anticorps Souris Monoclonal détectant NUMA1 dans ELISA (Detection). Adapté pour Humain.

Aperçu rapide pour NUMA1 anticorps (ABIN7670701)

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUMA1 est non-conjugé

Application: ELISA (Detection)

Clone: 6D4

Détail du produit anti-NUMA1 anticorps

Fonction: NUMA/NMP22 Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogène: Recombinant Human NUMA/NMP22 protein expressed by E.coli

Isotype: IgG2b

Information d'application

Indications d'application: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Date de péremption: 12 months

Détails sur NUMA1

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Autre désignation: NUMA/NMP22

Sujet: NucLear mitotic apparatus protein 1,NucLear matrix protein-22(NMP-22),NucLear mitotic apparatus protein,SP-H antigen,NUMA1,NUMA,Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division.Functions to tether the minus ends of MTs at the spindle poles,which is critical for the establishment and maintenance of the spindle poles.Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner.In metaphase,part of a ternary complex composed of GPSM2 and G(i) alpha proteins,that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles,and hence regulates the correct oritentation of the mitotic spindle.During anaphase,mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2),and hence participates in the regulation of the spindle elongation and chromosome segregation.Binds also to other polyanionic phosphoinositides,such as phosphatidylinositol 3-phosphate (PIP),lysophosphatidic acid (lPA) and phosphatidylinositol triphosphate (PIP3),in vitro.Also required for proper orientation of the mitotic spindle during asymmetric cell divisions.Plays a role in mitotic MT aster assembly. Involved in anastral spindle assembly. Positively regulates TNKS protein localization to spindle poles in mitosis. Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role,occupies the majority of the nuclear volume. Required for epidermal differentiation and hair follicle morphogenesis.

UniProt: Q14980

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase