ALIX anticorps

N° du produit ABIN7673519

Cet anticorps Souris Monoclonal détecte spécifiquement ALIX dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ALIX anticorps (ABIN7673519)

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ALIX est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 8H4

Détail du produit anti-ALIX anticorps

Fonction: PDCD6IP antibody

Purification: protein A+G purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: programmed cell death 6 interacting protein

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur ALIX

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Autre désignation: PDCD6IP

Sujet:

Synonyms: Programmed cell death 6-interacting protein (PDCD6-interacting protein)|ALG-2-interacting protein 1|ALG-2-interacting protein X|Hp95|PDCD6IP|AIP1|ALIX|KIAA1375

Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Poids moléculaire: 100 kDa

ID gène: 10015

UniProt: Q8WUM4

Pathways: Signalisation p53, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation