PKM2 anticorps

N° du produit ABIN7674413

Cet anticorps Lapin Polyclonal détecte spécifiquement PKM2 dans WB, IHC, ELISA, IF et IP. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour PKM2 anticorps (ABIN7674413)

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKM2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-PKM2 anticorps

Fonction: PKM2-specific antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: PKM2 pyruvate kinase, muscle

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:4000, IP: 1:200-1:1000, IHC: 1:100-1:400, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PKM2

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Autre désignation: PKM2

Sujet:

Synonyms: Pyruvate kinase PKM|Cytosolic thyroid hormone-binding protein (CTHBP)|Opa-interacting protein 3 (OIP-3)|Pyruvate kinase 2/3|Pyruvate kinase muscle isozyme|Threonine-protein kinase PKM2|Thyroid hormone-binding protein 1 (THBP1)|Tumor M2-PK|Tyrosine-protein kinase PKM2|p58|PKM|OIP3|PK2|PK3|PKM2

Background: PKM2, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1, however, the primary isoform from four independent tumours is PK-M2.(PMID:18337823) PKM2, Pyruvate kinase isozymes M1/M2, has 2 isoforms.The immunogen of this antibody is M2 isoform, also called PKM2. This antibody is specific to PKM2 isoform.

Poids moléculaire: 58 kDa

UniProt: P14618

Pathways: L'effet Warburg