CD72 anticorps (FineTest®700)

N° du produit ABIN7675253

Cet anticorps anti-CD72 est un anticorps Souris Monoclonal détectant CD72 dans FACS. Adapté pour Humain.

Aperçu rapide pour CD72 anticorps (FineTest®700) (ABIN7675253)

Antigène: CD72 (CD72 Molecule (CD72))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD72 est conjugé à/à la FineTest®700

Application: Flow Cytometry (FACS)

Clone: 3F3

Détail du produit anti-CD72 anticorps (FineTest®700)

Fonction: FineTest®700 Anti-Human CD72 Antibody

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 %BSA, pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: 4 °C

Stockage commentaire: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CD72

Antigène: CD72 (CD72 Molecule (CD72))

Autre désignation: CD72

Sujet:

Synonyms: Lyb-2|Ly-19.2|Ly-32.2

Background: CD72 is a 39-43 kD type II membrane glycoprotein. It is a disulfide-linked homodimer belonging to C-type lectin family. CD72 is a pan-B cell marker expressed on pre-pre-B cells throughout B cell differentiation with the exception of plasma cells. It is also expressed on follicular dendritic cells, splenic red pulp macrophages (but not on peripheral blood monocytes), and liver Kupffer cells. CD72, a negative coreceptor of B cells, contains immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain which has been shown to recruit the tyrosine phosphatase SHP-1. Ligation of CD72 with its ligand regulates CD72 tyrosine dephosphorylation and SHP-1 dissociation to promote B cell activation and proliferation. CD100 and CD5 have been shown to be CD72 ligands. The CD100-CD72 interaction plays a role in maintenance of B cell homeostasis.

Poids moléculaire: 0

ID gène: 971

UniProt: P21854

Pathways: BCR Signaling