LGR5 anticorps (AA 810-907)

N° du produit ABIN737916

Détail du produit anti-LGR5 anticorps

Antigène: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Épitope: AA 810-907

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LGR5 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse GPR49

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-LGR5 (ABIN737916)

Su, Li, Liu, Ren, Tian, Liu, Qiu: "Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype." dans: Oncology reports, Vol. 36, Issue 1, pp. 72-8, (2016) (PubMed).

Détails sur LGR5

Antigène: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Autre désignation: GPR49/LGR5 (LGR5 Produits)

Synonymes: anticorps lgr5-a, anticorps lgr5a, anticorps FEX, anticorps Gpr49, anticorps GPR49, anticorps GPR67, anticorps GRP49, anticorps HG38, anticorps leucine-rich repeat containing G protein-coupled receptor 5 L homeolog, anticorps leucine rich repeat containing G protein coupled receptor 5, anticorps leucine rich repeat containing G protein-coupled receptor 5, anticorps lgr5.L, anticorps Lgr5, anticorps LGR5

Sujet:

Synonyms: FEX, Gpr49, Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, Orphan G-protein coupled receptor FEX, Lgr5

Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

ID gène: 14160

UniProt: Q9Z1P4

Pathways: Signalisation WNT